When you're tired of taking and retaking pills every few hours to deal with long-lasting aches and pains, Aleve can help. Just 1 caplet is strong enough to provide pain relief that can last up to 12 hours, which means no more stopping throughout the day to take more caplets. Aleve is different, unlike Tylenol (Acetaminophen) and Advil (ibuprofen), each Aleve caplet has the strength to last 12 hours. Aleve is an over-the-counter (OTC), nonsteroidal anti-inflammatory drug (NSAID) that provides temporary relief from minor aches and pains. It also temporarily reduces fever and provides headache relief.