Our exclusive formula provides long-lasting control against insects, diseases and mites in one easy step. BioAdvanced 3-In-1 Insect, Disease and Mite Control 32 ounce Ready-to-Spray treats up to 192 rose bushes. It is an exclusive formula that provides long-lasting control against insects, cures and prevents diseases and controls spider mites in one easy step. It's systemic rainproof protection lasts up to 30 days, so growing trees, shrubs, flowers and roses has never been easier. BioAdvanced. Get More From The Blue Bottle®.