Caplets for Fast Migraine Relief Excedrin Migraine Caplets for Migraine Headache Relief provide migraine relief fast, making Excedrin Migraine the number 1 neurologist recommended OTC treatment for migraines (1). Excedrin works in 3 ways to relieve migraines: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance the pain relief effect. Available in convenient caplet form, this powerful migraine medicine delivers a specialized triple action formula containing two pain relievers and an amplifier. These Excedrin caplets combine aspirin and acetaminophen with caffeine to provide migraine relief, including migraine headache pain, sensitivity to light and sound, and nausea. For some, this migraine headache relief medicine starts relieving migraine pain in 30 minutes. Get migraine relief fast with Excedrin, the headache expert. (1) Among OTC medicine for migraines IQVIA, Inc., 2018