This book constitutes the proceedings of the 10th International Conference on Security and Cryptography SCN 2016 held in Amalfi Italy in August/September 2016. The 30 papers presented in this volume were carefully reviewed and selected from 67 submissions. They are organized in topical sections on encryption; memory protection; multi-party computation; zero-knowledge proofs; efficient protocols; outsourcing computation; digital signatures; cryptanalysis; two-party computation; secret sharing; and obfuscation.