Differin Acne Spot Treatment with 10% Benzoyl Peroxide helps to clear and treat acne blemishes, blackheads, whiteheads & clogged pores. Formulated with the maximum strength benzoyl peroxide concentration available without a prescription, it starts working immediately to kill acne-causing bacteria. This spot treatment targets acne on the face and should be used as a part of your daily routine to assist with acne treatment. Start by cleansing your skin, then cover the entire affected area with a thin layer. Apply once daily, gradually increasing to two or three times a day as needed. Apply sunscreen before going outside.