Recently there has been renewed interest in the role played by bone in the development of osteoarthritis including targeting bone as a potential therapeutic approach. The molecular and cellular approaches toward the relationship of joint and bone problems distinguish this from other books on osteoarthritis or skeletal medicine. Emphasis on genetics and newer viewpoints and approaches gives a wider viewpoint and may make possible novel approaches to solving a clinical problem. Topics discussed include the role of bone in osteoarthritis ranging from basic cell and molecular biology to genetics and biomechanics. The book will enable the novice to become oriented with the subject and allow the practitioner to update knowledge.