This manual provides technical protocols for musculoskeletal research on a translational basis i.e. a disease-orientated approach. It offers guidance on various laboratory techniques including cell culture and molecular biology histology and histomorphometry microscopy and bioimaging laboratory animal models CT- and MRI-based densitometry and microarchitectural analysis biomechanics and functional analysis of orthopedic kinesiology etc. The content is simple and straightforward with illustrations and step-by-step procedures as an easy experimental reference for personnel in basic and clinical musculoskeletal research and education. This book will provide a unique multidisciplinary platform for various professions -- not only orthopedics but also biomedical engineering and biomaterial sciences -- involving both basic and clinical medicine.